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28 results

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Page 1
Effect of host genetics on the gut microbiome in 7,738 participants of the Dutch Microbiome Project.
Lopera-Maya EA, Kurilshikov A, van der Graaf A, Hu S, Andreu-Sánchez S, Chen L, Vila AV, Gacesa R, Sinha T, Collij V, Klaassen MAY, Bolte LA, Gois MFB, Neerincx PBT, Swertz MA; LifeLines Cohort Study; Harmsen HJM, Wijmenga C, Fu J, Weersma RK, Zhernakova A, Sanna S. Lopera-Maya EA, et al. Nat Genet. 2022 Feb;54(2):143-151. doi: 10.1038/s41588-021-00992-y. Epub 2022 Feb 3. Nat Genet. 2022. PMID: 35115690

To robustly characterize these effects, we performed a genome-wide association study of 207 taxa and 205 pathways representing microbial composition and function in 7,738 participants of the Dutch Microbiome Project. Two robust, study-wide significant (P < 1.89 10(-10))

To robustly characterize these effects, we performed a genome-wide association study of 207 taxa and 205 pathways representing microbial com …
Health-related quality of life is linked to the gut microbiome in kidney transplant recipients.
Swarte JC, Knobbe TJ, Björk JR, Gacesa R, Nieuwenhuis LM, Zhang S, Vila AV, Kremer D, Douwes RM, Post A, Quint EE, Pol RA, Jansen BH; TransplantLines investigators; de Borst MH, de Meijer VE, Blokzijl H, Berger SP, Festen EAM, Zhernakova A, Fu J, Harmsen HJM, Bakker SJL, Weersma RK. Swarte JC, et al. Nat Commun. 2023 Dec 2;14(1):7968. doi: 10.1038/s41467-023-43431-8. Nat Commun. 2023. PMID: 38042820 Free PMC article. Review.
Gut microbiome distance to the general population is highest among KTR with an impaired physical HRQoL (R = -0.20, P = 2.3 10(-65)) and mental HRQoL (R = -0.14, P = 1.3 10(-3)). ...
Gut microbiome distance to the general population is highest among KTR with an impaired physical HRQoL (R = -0.20, P = 2.3 10(-65)) a …
Gut feelings: the relations between depression, anxiety, psychotropic drugs and the gut microbiome.
Brushett S, Gacesa R, Vich Vila A, Brandao Gois MF, Andreu-Sánchez S, Swarte JC, Klaassen MAY, Collij V, Sinha T, Bolte LA, Wu J, Swertz M, de Kroon MLA, Reijneveld SA, Wijmenga C, Weersma RK, Fu J, van Loo HM, Kurilshikov A, Zhernakova A. Brushett S, et al. Gut Microbes. 2023 Dec;15(2):2281360. doi: 10.1080/19490976.2023.2281360. Epub 2023 Nov 28. Gut Microbes. 2023. PMID: 38017662 Free PMC article.

After additional adjustment for functional gastrointestinal disorders and irritable bowel syndrome, these relations remained either statistically (FDR <0.05) or nominally (P < 0.05) significant. Overall, multiple bacterial species and functional modules were associat

After additional adjustment for functional gastrointestinal disorders and irritable bowel syndrome, these relations remained either statisti …
Mucosal host-microbe interactions associate with clinical phenotypes in inflammatory bowel disease.
Hu S, Bourgonje AR, Gacesa R, Jansen BH, Björk JR, Bangma A, Hidding IJ, van Dullemen HM, Visschedijk MC, Faber KN, Dijkstra G, Harmsen HJM, Festen EAM, Vich Vila A, Spekhorst LM, Weersma RK. Hu S, et al. Nat Commun. 2024 Feb 17;15(1):1470. doi: 10.1038/s41467-024-45855-2. Nat Commun. 2024. PMID: 38368394 Free PMC article.

Analysis of transcript-bacteria interactions identifies six distinct groups of inflammation-related pathways that are associated with intestinal microbiota (adjusted P < 0.05). An increased abundance of Bifidobacterium is associated with higher expression of genes invol

Analysis of transcript-bacteria interactions identifies six distinct groups of inflammation-related pathways that are associated with intest …
GDP-mannose dehydrogenase is the key regulatory enzyme in alginate biosynthesis in Pseudomonas aeruginosa: evidence from metabolite studies.
Tatnell PJ, Russell NJ, Gacesa P. Tatnell PJ, et al. Microbiology (Reading). 1994 Jul;140 ( Pt 7):1745-54. doi: 10.1099/13500872-140-7-1745. Microbiology (Reading). 1994. PMID: 7521247 Free article.
In the present study the algD gene has been cloned into the broad-host-range expression vector pMMB66EH and GMD overexpressed in mucoid and genetically-related non-mucoid strains of P. aeruginosa. The metabolic approach of P. J. Tatnell, N. J. Russell & P
In the present study the algD gene has been cloned into the broad-host-range expression vector pMMB66EH and GMD overexpressed in mucoid and …
Inflammatory mediators in nasal secretions of patients with nasal polyposis with and without aspirin sensitivity.
Perić A, Gaćeša D, Cvetković G, Vojvodić D. Perić A, et al. Immun Inflamm Dis. 2023 Feb;11(2):e791. doi: 10.1002/iid3.791. Immun Inflamm Dis. 2023. PMID: 36840483 Free PMC article.
The concentrations of eosinophil cationic protein (ECP), tryptase, heat shock protein 70 (HSP70), substance P and Clara cell protein 16 (CC16) were determined in nasal secretions. RESULTS: Higher concentrations of ECP, tryptase, and HSP70 were measured in the AERD patients …
The concentrations of eosinophil cationic protein (ECP), tryptase, heat shock protein 70 (HSP70), substance P and Clara cell protein …
Gut dysbiosis associates with cytokine production capacity in viral-suppressed people living with HIV.
Zhang Y, Andreu-Sánchez S, Vadaq N, Wang D, Matzaraki V, van der Heijden WA, Gacesa R, Weersma RK, Zhernakova A, Vandekerckhove L, de Mast Q, Joosten LAB, Netea MG, van der Ven AJAM, Fu J. Zhang Y, et al. Front Cell Infect Microbiol. 2023 Jul 31;13:1202035. doi: 10.3389/fcimb.2023.1202035. eCollection 2023. Front Cell Infect Microbiol. 2023. PMID: 37583444 Free PMC article.
RESULTS: Compared with 190 age- and sex-matched controls and a second independent control cohort, PLHIV showed microbial dysbiosis that was correlated with viral reservoir levels (CD4(+) T-cell-associated HIV-1 DNA), cytokine production capacity, and sexual behavior. Notably, we …
RESULTS: Compared with 190 age- and sex-matched controls and a second independent control cohort, PLHIV showed microbial dysbiosis that was …
Efficacy of hypertonic (2.3%) sea water in patients with aspirin-induced chronic rhinosinusitis following endoscopic sinus surgery.
Perić A, Kovačević SV, Barać A, Gaćeša D, Perić AV, Jožin SM. Perić A, et al. Acta Otolaryngol. 2019 Jun;139(6):529-535. doi: 10.1080/00016489.2019.1605454. Epub 2019 Apr 29. Acta Otolaryngol. 2019. PMID: 31035841 Clinical Trial.

RESULTS: We found significantly lower total symptom score (TSS) during the 7th (p = .009), 14th (p = .003), 21st (p < .001) and the 28th day (p = .001), lower total endoscopic score (TES) on the 21st (p = .002) and 28th day (p = .001),

RESULTS: We found significantly lower total symptom score (TSS) during the 7th (p = .009), 14th (p = .003), 21st (p &lt …
Donor genetic variants as risk factors for thrombosis after liver transplantation: A genome-wide association study.
Li Y, Nieuwenhuis LM, Voskuil MD, Gacesa R, Hu S, Jansen BH, Venema WTU, Hepkema BG, Blokzijl H, Verkade HJ, Lisman T, Weersma RK, Porte RJ, Festen EAM, de Meijer VE. Li Y, et al. Am J Transplant. 2021 Sep;21(9):3133-3147. doi: 10.1111/ajt.16490. Epub 2021 Feb 11. Am J Transplant. 2021. PMID: 33445220 Free PMC article.
Downstream prioritization strategies identified biologically plausible candidate genes, among which were AK4 (rs11208611-T, p = 4.22 10(-05) ) which encodes a protein that regulates cellular ATP levels and concurrent activation of AMPK and mTOR, and RGS5 (rs10917696-C, …
Downstream prioritization strategies identified biologically plausible candidate genes, among which were AK4 (rs11208611-T, p = 4.22 …
28 results